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The active ingredient in these medications is semaglutide, which works in the brain to impact satiety

MeseguerSNavarro-GonzlezCPanaderoJVillarroyaMBoutoualRSnchez-AlczarJAet al

Manufactured by Eli Lilly, Zepbound was approved by the federal Food and Drug Administration (FDA) on Nov

through mitochondrial ROS-mediated SERCA2a oxidation, it reduces ATPase activity, causing reduced systolic Ca 2+ release and diastolic Ca 2+ leakage, triggering arrhythmias (Tamayo et al., 2020)

however, many patients retain 5070% of their weight loss through sustained habit change and continued exercise

The climbing demand for these drugs driven by expanded indications and increasing off-label use for cosmetic weight loss, led to insurmountable shortages on the market