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Although the decrease in alcohol drinking is slightly less pronounced in female compared to male rats, this is the first study demonstrating a decline in female rats (47)

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In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]

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In recent years, mass spectrometry-based quantification methodsboth label-based and label-freehave become essential tools in proteomics