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The only real issue has been the medicine not always being readily available

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J Clin Endocrinol Metab (2010) 95:E2631

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Beyond BDNF, Semax normalizes anxiety and depression-like behavior through monoamine tuning

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GLP-1RAs improve hyperglycemia by enhancing insulin secretion through increases in -cell cytoplasmic cyclic adenosine monophosphate [53], which activates protein kinase A (PKA) and, thus, increases in intracellular calcium and triggers insulin exocytosis in a glucose-dependent manner [54]

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However, the clinical utility of native GLP-1 is limited due to its extremely short half-life (only a few minutes), as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

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