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--- ## Storage Rules After Reconstitution | Condition | Temperature | Maximum Duration | |-----------|-------------|-----------------| | Refrigerator (ideal) | 3646F (28C) | 28 days from reconstitution | | Room temperature (brief excursion) | Under 77F (25C) | 2 hours maximum | | Frozen | Below 32F | Never discard immediately | **Storage do's:** - Store in the original vial, upright - Keep in the refrigerator door shelf or middle shelf avoid the back where freezing can occur - Protect from light (store in original box or wrap in foil) - Remove from fridge just before drawing your dose

The kidney-protective properties of LEO against cell death appear to be mediated through diminished NLRP3 and inflammatory mediators, improving mitochondrial function, and attenuating endoplasmic reticulum (ER) stress

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doi:10.2337/DC20-S002 2

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