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Some patients require surgical intervention (Nissen fundoplication) for severe GERD before they can tolerate any GLP-1 medication at therapeutic doses

PMID: 16423593

They have side effects, but on balance, the positives of the health effects outperformed the risks. Bolling, who practiced adolescent obesity medicine for more than 20 years before retiring, says that, starting in the late 1990s, doctors noticed an explosion of obesity prevalence in kids

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