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According to the Mayo Clinic, parenteral vitamin B12 therapy is clinically indicated for treating deficiency caused by pernicious anemia, gastrointestinal disorders such as tropical sprue, and conditions resulting in malabsorption like pancreatic insufficiency

My understanding is that this should be done routinely, especially if you're on B12 in high doses, but most GP's don't know this and don't do it

Frequency: Once per week maximum for at-home treatment

S., Erickson, B

Vitamin B12 promotes brain health through its role in the production of neurotransmitters (specific chemicals in our nervous system) and myelin, the protective membrane around nerves