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Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide is a dual-action medication that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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The combination product factor Adding to the confusion, Sanofi (the same company that makes Toujeo) also manufactures Soliqua 100/33

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However, a 57% reduction in renal events was observed compared to those receiving only GLP-1 RAs (114)