These include: Vegetarians and Vegans: Since vitamin B12 is primarily found in animal products, those following a vegetarian or vegan diet may be at risk of deficiency
Frontiers in Pharmacology, 13, 870599
Pre-existing thyroid disease : The SmPC notes that thyroid adverse events, including goitre, may be more frequent in patients with pre-existing thyroid disease
doi: 10.2165/00002018-200831010-00005 29 BillesSKSinnayahPCowleyMA
This strategy of layering the cell suspension on top of a barrier has been extended to the use of OptiPrep for isolation of DCs from lymph [12], bone marrow [13], bone marrow cell cultures [14], spleen [15], thymus [16] and lung [17]
Getting through the adjustment period while keeping protein high and continuing to exercise is a win