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Discussion and future direction Accumulating preclinical and early clinical work suggests that drugs targeting gut-brain peptide signaling are promising therapeutics for the treatment of AUD

doi: 10.7554/eLife.55357 86

We also include nutritional counseling, exercise recommendations, and weight loss drugs, including semaglutide and tirzepatide

For individuals with obesity, adjusted body weight can also be used to determine daily protein needs, and is calculated as target body weight plus 25% of the difference between current and target body weight

Over time, patterns emerge that help distinguish drug effects from disease activity