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This article summarizes published preclinical findings and analytical-quality considerations

When antibiotics, particularly sulphur drugs, are used for extended periods, the normal synthesis of Folic acid in the gut will be reduced and the requirements for Folic Acid are increased.

Oral supplements must be absorbed through the digestive tract, which can be an inefficient process, especially for individuals with absorption issues

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They share the same receptor pathway, and doubling up dramatically increases the risk of severe gastrointestinal side effects without proportional benefit