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A major limiting factor in the development of new treatments is the lack of predictive pre-clinical models that accurately reflect human disease with regard to liver histology, pathophysiology, and metabolic abnormalities

The latter most often develop in fair-skinned individuals, usually as a result of sun exposure

Family members might express concern about changed behavior, leading to conflict and further isolation

Waltham, MA, USA: Academic Press (2018)

The lack of conclusive data necessitates caution

Although GLP-1 RAs have a similar mechanism of action, there are substantial differences between the various medications in this family