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We note that a leucine zipper motif is fused to the FnIII-3 domain of the IR ectodomain, which is designed to stabilize the active conformation of the engineered IR

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This medication can be a more suitable option if you're considering tirzepatide for weight loss

Int J Obes (Lond) 45:170

Or if you are losing weight too rapidly (more than 1-2% of body weight per week consistently), which increases the risk of gallstones, muscle loss, and metabolic disruption