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Deficiency of intracellular glutathione can worsen oxidative stress and accelerate cellular death in diseases such as Alzheimer disease, Parkinson disease, liver disease, cystic fibrosis, sickle cell anemia, HIV/AIDS and diabetes

Kim MS, Lim JS, Hyung WJ, Lee YC, Rha SY, Keum KC, et al

Ninomiya T, Kiyohara Y, Kubo M, Yonemoto K, Tanizaki Y, Doi Y, Hirakata H, Iida M

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203,480 Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid produced by cytochrome P450 (CYP) epoxygenases, are predominantly synthesized in endothelial cells

The oxidation reaction between Fe 2+ and H 2 O 2 could generate hydroxyl radicals that yield hydrogen from PUFAs to form lipid radicals (L)