For instance, genetic ablation of GPX4 promotes the accumulation of oxidized cardiolipin within mitochondriaa [54], and lipid peroxidation has been reported to emerge initially in mitochondrial membranes before propagating to other cellular compartments
Diabetologia 55 , 24452455 (2012)
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Combined, these data reveal new interactions between cellular redox homeostasis, secondary metabolism and metal ion homeostasis