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This is particularly relevant for: Short-acting agents (exenatide immediate-release, lixisenatide) May require timing separation from oral medications, particularly those requiring rapid absorption Weekly agents (semaglutide, dulaglutide, exenatide extended-release) Generally have minimal impact on oral contraceptive effectiveness Warfarin/coumarin anticoagulants More frequent INR monitoring may be advised when starting GLP-1 therapy Oral semaglutide (Rybelsus) has specific administration requirements (taking on an empty stomach with a small amount of water) to ensure proper absorption

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Once viewed solely as a hormone that raises blood sugar, glucagon is now recognized as an important regulator of energy balance, fat metabolism, and liver health

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Some patients can get off these medications after losing and maintaining their weight for a while, but you should work with your clinician to make sure youre going off them the right way

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Thyroid Cancer: As with other GLP-1 medications, animal studies have shown a theoretical risk of thyroid tumours

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