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Mean age was 5610 years, BMI 33.06.3 kg/m 2 , HbA1c 8.00.7%, and diabetes duration 7.65.5 years, and individuals were on a stable dose of metformin (1,500 mg or maximum tolerated) with or without SGLT-2i
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Given the repression of the proneurogenic bHLH by H3K27me3, it is plausible that histone demethylases could be involved in neuronal fate determination through removal of the H3K27me3 marks and activation of pro-neurogenic bHLH factors
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