Participants received either oral semaglutide 25 mg or a placebo once daily for 71 weeks, alongside lifestyle changes, with the primary weight outcome measured at week 64
GLP-1 agonist medications, known by the brand names Ozempic, Trulicity, and Wegovy, have proved to be effective for weight loss as well as managing Type 2 diabetes
Acidity and nucleophilic reactivity of glutathione disulfide
Underweight or BMI too low Wegovy is approved only for: BMI of 30+ , or BMI of 27+ with a weight-related condition If you fall below those BMI levels , your provider may not prescribe Wegovy, even off-label
This off-label combination requires careful clinical evaluation, individualized timing, and close monitoring to optimize metabolic outcomes while managing potential risks in patients with altered gastrointestinal anatomy
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