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Current clinical trials in CAR-T cell therapy are focused on several key areas: Enhancing T cell effector function and persistence: Second-generation CAR-T cell therapies incorporate co-stimulatory molecules (such as CD28 or 4-1BB) into the CAR structure, significantly enhancing T cell activation and persistence

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Effect of antidepressant drugs Treatment of mice with fluoxetine, sertraline or imipramine resulted in significant decrease in the immobility time compared to vehicle control group (Fig