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In PD, along with -synuclein accumulation, there is associated inflammation, synaptic dysfunction, dopaminergic neuronal loss, and some data to suggest insulin resistance

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Rectangles denotes the compounds that were quantified, and bold red rectangles denote the metabolites that differed between patients and controls

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death