In the previous Phase 2 study of 18 people who had PBH after RYGB surgery and the Phase 2b study of 16 people who had PBH following a variety of GI surgeries (including RYGB, sleeve gastrectomy, esophagectomy, Nissen fundoplication, and gastrectomy), treatment with avexitide during a 28-day treatment period led to statistically significant reductions in hypoglycemic events with a well-tolerated safety profile, including no discontinuations
0.4 kg with placebo) in people with T2D, without delay in gastric emptying or nausea and vomiting [37]
This can be due to several factors
2021 Jul 13;36(2):109374
2021;12:1321 Chen J, Ren H, Zhou P, Zheng S, Du B, Liu X, et al
Retatrutide produced 28.7% body weight loss at 68 weeks in Phase 3 trials