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Because fasted-state absorption allows the peptide to bind NNMT enzymes without interference from competing substrates in the gut

International journal of nanomedicine

Liu J, Li C, Qu W, Leslie E, Bonifant CL, Buzard GS et al

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As the only cytochrome P450 enzyme involved in all known sterol biosynthetic pathways across eukaryotes, CYP51A1 performs a critical demethylation step that enables the formation of cholesterol in mammals and ergosterol in fungi