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For example, biased GLP-1R signalling is observed following stimulation with exendin-phe1, which carries a phenylalanine substitution at position 1 of exendin-4, causing a similar reduction in receptor internalisation and increased plasma membrane recycling to GLP-1R V229A (60)

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Nature 407 , 908913 (2000)

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Read articleListen Press Release Phenomix Sciences Announces First Prospective Clinical Study of Semaglutide Using MyPhenome Test PRNewswire - Menlo Park, Calif