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Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases

In skin, the ones that matter act as signaling molecules: they bind receptors or interact with the extracellular matrix and change what fibroblasts do

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GIPR adenylyl cyclase cAMP , p38 MAPK, PKB, PKA, PI-3K - A2 ( McIntosh ' -Vitam Horm 2009)

However, men with significantly low levels or structural causes of hypogonadism typically still require hormone therapy

Several approaches can support libido during treatment