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Some trials have shown modest improvements in cognition or motor function, but others have found no meaningful effect on disease progression

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Mood and Sleep Disorders: Consider dosage reduction or discontinuation for clinically significant or persistent mood or sleep disorder symptoms ( 5.4)

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

New effective therapies for lipodystrophy patients are therefore a clinical imperative (4143)

Clinically detectable appetite suppression and weight changes typically emerge from 0.5 mg onward