The other GLP-1 peptide demonstrated to have clinical potential for type 2 diabetes was GLP-1 (7-36)
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327 In the inflammatory environment, the M1 to M2 shift promoted by GLP-1 is crucial for reducing the expression of inflammatory factors such as IL-6, TNF-, and iNOS
The marked WL achieved with tirzepatide in the SURPASS trials led to the phase 3 SURMOUNT programme, assessing tirzepatide as treatment for obesity [16]
Our peer-reviewed JMIR study of the GLP-1RA-supported programme reported an average weight loss of 19.1% at 12 months among active subscribers, with 77.7% achieving at least 10% weight loss