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Deregulated mitochondrial microRNAs in Alzheimers disease: Focus on synapse and mitochondria
Additionally, SIRT1 deacetylates autophagy-related protein 5 (ATG5) and ATG12, increasing the ATG16-ATG5-ATG12 complex, thereby promoting autophagy
These functions are often disrupted in depression
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However, their activity consumes significant amounts of NAD + , leading to a depletion of cellular NAD + levels and impacting energy metabolism and cell survival 58
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