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SULT1A1 is believed to be the major enzyme associated with paracetamol sulphation, although SULT1A3/4 and SULT1E1 have also been implicated in the foetus and neonates [20, 35, 36]

In the event of any of these symptoms occurring, it is advised that the patient discontinue use immediately and seek medical attention

However, by using a rigorous emulated target trial design they reduced much of the bias common to observational studies, and results were consistent after further analyses, suggesting that they are robust

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