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its complex, with diverse phenotypes and pathologies driving individual experiences
Peer review Peer review information Nature Communications thanks Chen Zhao, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Fatty acids also have to compete with glucose for transport into the mitochondria
A major player in this process is PC, an anaplerotic enzyme that enables the beta cells to convert half of glucose-derived pyruvate into metabolites that participate in shuttles or cycles that provide intracellular messengers including NADPH, GTP, precursors of short-chain acyl-CoAs, lipids and amino acids which support K ATP -independent insulin secretion that may be equal in importance to ATP production by mitochondria for insulin secretion
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In our youth, NAD+ levels are abundant, fueling our boundless energy and vitality
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