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Available online at: October 10, 2022)

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Bioavailability is higher, though the rapid peptidase degradation still limits systemic peptide exposure

That compares with six cases in patients prescribed non-GLP-1 diabetes drugs, calculated as a cumulative rate of 1.8%

Fewer events in the placebo arm of SURMOUNT-1 compared with ONeil, STEP 1 and STEP 8 for total gastrointestinal AEs and nausea AEs suggest that the relative safety of tirzepatide versus liraglutide and semaglutide may be underestimated for these outcomes (see Supplementary Material Table S3)

Yeast One-Hybrid Assay Yeast one-hybrid assay was conducted to investigate the individual interactions between MrMYB1.1 and MrGST1 promoter according to the Matchmaker @ Gold Yeast One-Hybrid Library Screening System (Clontech) manufacturers protocol