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2.2.1 Calor: endogenous pyrogens/cytokines Fever is largely mediated by endogenous pyrogensproinflammatory cytokines that are released by immune cells in response to infection, tissue damage, or autoimmune activity

This work is dedicated to members of my family: Anna (daughter), Jerzy (son) and granddaughters: Susanna Zachara-Szczakowski MD, Agatha Zachara-Szczakowki BCom, who were born, studied and are working in Canada

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Patients suffering from major depression had reduced levels of immunoreactive DSIP compared to control subjects, as shown in cerebrospinal fluid (CSF) analysis

Glutathione is excellent at the removal of reactive species, which are free radicals AKA JUNK in our body that needs to be cleared out such as xenobiotic compounds (AKA foreign chemical substances we ingest from our environment such as pesticides, VOCs etc.), and much more