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*Correspondence: Linlin Hao, [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Introduction Over the past three decades, the world has undergone substantial demographic, economic, political, socio-cultural, and environmental changes that are affecting diet, nutrition, and health more broadly

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doi: 10.1016/j.clinbiochem.2012.01.016