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As already mentioned, the only residue of the large subunit reported to participate in catalysis is the conserved arginine (Arg114 in EcGGT, Arg113 in BsGGT, Arg109 in BlGGT)

This added follow-up should be noted down in the total expenditure of the treatment

Koperska A, Moszak M, Seraszek-Jaros A, et al

Disorders of purine metabolism are associated with considerable variations in the concentration of serum uric acid (SUA) because uric acid is the ultimate product of purine catabolism in humans

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the variability may be higher or lower in other regions of the brain