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When the concentration of melanin is reduced, the pigment in ones skin is also reduced, resulting in a lighter complexion

Furthermore, blockade of ET-1 receptors, mainly ETA, using antagonists such as atrasentan has demonstrated efficacy in reducing blood pressure and proteinuria, supporting the role of ET-1 in vascular and renal injury in CRHM syndrome (105)

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Retrieved from: Singh, S

[DOI] [PubMed] [Google Scholar] 132.Escartin C., Joon Won S., Malgorn C., Auregan G., Berman A.E., Chen P.C., Deglon N., Johnson J.A., Won Suh S., Swanson R.A

Comp Immunol Microbiol Infect Dis 22, 4161