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10.1161/CIRCULATIONAHA.111.041418 174 ShahZ.PinedaC.KampfrathT.MaiseyeuA.YingZ.RacomaI.et al (2011b)
[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
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It can develop in anyone who performs repetitive arm, wrist, or hand movementsfrom athletes and weightlifters to carpenters, mechanics, and office workers
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