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It also highlights individual sensitivity and dose-dependency as modifying factors influencing the intensity of the effects

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The procedure usually leads to significant weight loss (greater than with a GLP-1) and improvements in obesity-related conditions, such as type 2 diabetes, sleep apnea, and hypertension, potentially reducing future healthcare costs

25,26 Carriage of the 3R and insertion alleles for these variants results, respectively, in higher translation efficiency and negatively altered mRNA stability

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Progressive change of intra-islet GLP-1 production during diabetes development