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TB-4: Clinical Data for Unrelated Endpoints Meaningful human trial data for full-length TB-4 (corneal-healing Phase 2/3 as RGN-259, plus cardiac and wound-repair programs) Clean Phase 1 safety Cosmetic dosing is extrapolated from these programs Note: Full-length trial data does not transfer to the TB-500 fragment, so verify vial identity

J Sol-Gel Sci Technology (2022) 12

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Potential Risks and Unknowns Because TB500 influences angiogenesis and cell proliferation , some researchers have raised theoretical concerns about: Promoting unwanted cell growth (e.g., in precancerous tissues) Interfering with natural inflammatory processes during healing Suppressing immune responses with long-term or high-dose use There is no conclusive evidence showing carcinogenicity, but as with any peptide that affects growth and regeneration, caution is warranted especially if theres a history of tumors or systemic disease

Are these peptides intended for human use

FASEB J 2011