However, patients with preexisting cardiovascular disease should be carefully evaluated for potential risks and benefits before initiating treatment
Men with a personal or strong family history of medullary thyroid cancer should avoid GLP-1 agonists due to animal study signals, though human data remain reassuring
The SELECT trial (N=17,604), published in the New England Journal of Medicine in 2023, showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in overweight or obese adults without diabetes over a median follow-up of 34.2 months
Among the many advantages, patients often witness significant, sustained weight loss, surpassing traditional single-agent weight loss medications with an impressive body weight reduction of 15% to 20%
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