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Participants had not reached a weight loss plateau at the end of the study, indicating further weight loss may have been possible with continued treatment

The mechanisms of these effects are largely unknown

Mechanisms and clinical implications of gut-brain interactions

Additional endpoints should include effects on treatment-related toxicity, quality of life, disease-free survival (DFS), and overall survival (OS)

This higher strength may be considered for people who have tolerated treatment well but still require additional weight reduction support or have experienced slower progress over time

A MASLD substudy within the phase 2 obesity trial of retatrutide provided compelling evidence of hepatic benefits