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YangYWengWPengJHongLYangLToiyamaYet al Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-B, and Up-regulating expression of MicroRNA-21

Most findings for both MOTS-c and 5-Amino-1MQ come from animal models (primarily mice)

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Osteogenesis in sintered bone combined with bovine bone morphogenetic protein

Kong et al., similarly uncovered synergy between a complex I inhibitor and a mito-antioxidant in cancer cells, suggesting their ability to reduce mitochondria-derived H 2 O 2 levels as a potential mechanism of action (28)

No long-term knee-specific safety data exists