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Future studies need to further identify more brain-specific epigenetic regulatory genes and clarify their practical functional significance

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doi: 10.1161/atvbaha.118.311576 8 ZhangHLiGYuXYangJJiangAChengHet al

In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig