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Epac2 is also involved in K ATP channel closure (Kang et al., 2008), activation of PLC (Dzhura et al., 2010) and activation of ryanodine receptors (Tsuboi et al., 2003), all of which lead to Ca 2+ elevations
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In 2017, a study in Japan investigated the effects of tomato juice on sperm quality parameters in infertile men