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In addition, AKI was more common in the group diagnosed with type 2 diabetes mellitus (34.57%), followed by diabetes patients without classification (21.99%)

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She adds that starting with a lower dose of 2 mg/week instead of 4 mg/week may help mitigate adverse effects

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Glycogen synthase kinase-3, as a regulator of Nrf2, phosphorylates Nrf2 on the Neh6 domain to facilitate the attachment of -TrCP and recognition of Nrf2 by the ubiquitin ligase complex