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Semaglutide incorporates Aib at position 8 and a C18 fatty diacid chain at (Lys 26 ), conferring DPP-4 resistance and a 165 hours half-life enabling once-weekly dosing [13] Tirzepatide has Aib at the second residue and an acylated lysine (Lys 20 ) with a C18-C20 diacid resulting in a 120-hour half-life and weekly dosing
The metabolism of GLP-1 in the body is extremely rapid and the peptide gets inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4), even before leaving the gut
References 2
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