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6f) in HepG2 cells

"The fact that we've already identified variants in the drug target genes with a study of this size suggests there may also be a lot more to find," Auton said

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Stepping-Stones Towards Triple Agonism: A Summary of GLP-1/GIP and GLP-1/GCG Dual-Agonist Development The development of triple agonists for obesity has built upon successes of several dual combinations of entero-pancreatic hormone receptor agonists, in particular, GLP-1/GIP dual agonists and GLP-1/GCG dual agonists

Note that a dipeptidyl peptidase 4 (DPP-4) inhibitor can be discontinued when adding GLP-1RA because they are both incretin-based therapies and the DPP-4 inhibitor is redundant in that situation