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GLP-1 receptor agonists are drugs that mimic the action of our naturally occurring hormone, Glucagon-like peptide-1 (GLP-1)

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For example, increased activity of the endocannabinoid system does not influence GLP-1 concentrations 74,75 , and the effects of CB1 receptor antagonists on appetite, food intake, and weight are not mediated by GLP-1 76,77

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Such individuals who are not yet on insulin or other injectable diabetes medications do not need to learn self-injection techniques if they take the oral formulation of a GLP-1 receptor agonist such as semaglutide instead of the injectable version

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