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NMDA Receptor Modulation In brain research models, DSIPs effects appear to be at least partly mediated via NMDA receptors a glutamatergic ionotropic receptor family central to synaptic plasticity, learning and memory, and excitatory neurotransmission

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It interacts with receptors involved in stress response, circadian regulation, and sleep-wake cycling

Irritation here causes more discomfort than elsewhere and can affect vision temporarily

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