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If we are able to find a replacement supplier, the replacement supplier would need to be qualified and may require additional regulatory authority approval, which could result in further delay

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In preclinical research, this mechanism has been associated with selective apoptosis of senescent cells while preserving healthy cellular populations

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SURPASS-2 showed tirzepatide was superior to semaglutide 1mg for both A1C reduction (2.09% vs 1.86%) and weight loss (12.4% vs 6.2%) at the 15mg dose, establishing the clinical relevance of dual-agonism over selective GLP-1 agonism