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Immune checkpoint inhibitor-induced thyroiditis is associated with increased intrathyroidal T lymphocyte subpopulations

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Studies show that its NSP activity inhibition degree corresponds with neutrophil physiological renewal rates, achieving maximum inhibitory effects after 8 days of continuous treatment, validating that the compounds pharmacodynamic mechanisms align with design expectations ( 5.3 HSK31858 HSK31858 represents a novel oral small-molecule DPP1 inhibitor developed by Haisco Pharmaceutical Group in China ( Structural biology research reveals the unique binding mode of HSK31858 with DPP1