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Abstract Endoplasmic reticulum (ER) stress is associated with dysregulated metabolism, but little is known about how the ER responds to metabolic activity

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Severe caloric restriction accelerates muscle loss and may impair hormonal function

eGFR, estimated Glomerular Filtration Rate

For the IV regimen, a loading dose of 150 mg/kg in 200 cc is given for 15 minutes, followed by 50 mg/kg in 500 cc over 4 hours and then 100 mg/kg in 1000 cc over 16 hours.4,54,56,71 For the PO regimen, a loading dose of 140 mg/kg is given, followed by 70 mg/kg every 4 hours for a total of 18 total doses.54,56,71 Renal or hepatic dose adjustment is unnecessary