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The European Medicines Agency (EMA) has highlighted that the rising demand for these drugs, driven in part by their use for non-medical weight loss, is putting unprecedented pressure on suppliers

Efferocytosis of apoptotic cells is well documented to create an immunosuppressive and inflammation-resolving microenvironment, reprogramming macrophages [239, 240]

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Based upon, and as of the date of, this evaluation, our Chief Executive Officer and our Chief Financial Officer concluded that our disclosure controls and procedures as of December 31, 2023 are effective and the previously disclosed material weakness has been remediated as described below

Dec 2022;110:103376

For most people, the immediate effects are subtle